I wonder if barier Haki would work to prevent the contact altogether.
The Plagues are really broken. Put FM + post Udon training Luffy down in matter of seconds.
The Bullets would not pierce the skin.
If Queen could make it so that they pierce the skin the effect would work. Poisoning Big Mom was brought into question with Sanji's cake so they should not be immune.
Queen could also probably infest them if someone who is already infected manages to...
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