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Since Orochimaru's attempt to take Itachi's body, he took at least 2 more including a body comprised of Senju cells and refined ninjutsu like Edo Tensei. I'd say War Arc Orochimaru is him at his best.

Prime Orochimaru vs Itachi. With his arms sealed for 90% of the series, we never got to see what he could do. With a senju body and his jutsu back, it'd of been a good fight. Deidara vs Oonoki. Wish that continued from where it was. Pretty sure Oonoki was moments away from spanking, but I...