I don't think so. There is nothing hinting towards it. In fact, Yamato actually feels more like how Oden's son should have been. Her joining the crew is far better option for her character and the way its setup than being a retainer(which is outside what she wants).
I was thinking of macro dying at some point but gets reborn. But probably won't happen. This was a topic discussed especially regarding his DF, i.e. from the start the Phonenix DF has always been in one person's possession and that person just gets reborn. So macro is like the xth reincarnation...
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