@Admiral Lee Hung I believe this goes to Lemillion. Re-Destro’s quirk gives him great boosts to all his physical stats and he even has a devastating AoE attack.
Unfortunately, none of this really matters if he cannot even land a hit on Mirio, who can just phase through his attacks.
Problem for Mirio though, is that Re-Destro is an absolute tank, even more so when he wears his full suit of armor.
So my guess would be that it will end up a long drawn out fight where Mirio gradually wears down Re-Destro.
Poke him in the eyes, Mirio.