Orochimaru is referencing the Uchiha police force here.
We don't know of any other policy that turned into issues later on.
But, on the uchiha matter, we literally got the answer to that in that very same chapter lol
Like, yeah Tobirama was cautious of the Uchiha. But with good fucking reason. The sharingan, at least MS is literally fueled by hate.
All of Tobirama's concerns also came true btw. Madara was alive and was sowing seeds of rebellion through tobi.
Sure tobirama has some blame. But it is manga fact that uchiha were messed up from within lol. The start of their clan was because of hate and jealousy. Their progenitor was manipulated by Black Zetsu from the beginning. And their literal prophetic stone tablet was a manipulation tool made by Black Zetsu lol
You can't put that shit on Tobirama. The uchiha would have rebelled with or without Tobirama's policies. That was always their fate.