I think that the entire Chimera Ant event was a calculated orchestration with the intention of getting Isaac Netero killed. The location of the Chimera Ant Queen was perfect for an undetected colony to grow. And the Queen speculated herself that she has human DNA within her.
We know that, from the Dark Continent Expedition arc, Isaac Netero forbade his son, Beyond Netero, from going to the Dark Continent until after his father's death.
Also, during a conversation with Mizaistom and Kurapika, Mizaistom hinted that when Isaac Netero made that rule forbidding travel to the Dark Continent, he may have been hoping that his own son, Beyond, would try to kill him. (Isaac Netero was so wild and crazy, he would have been entertained by his own child trying to kill him.)
We also know, through the Dark Continent Expedition arc, that Beyond is said to have brought back calamities of his own from his trips to the Dark Continent.
During the Chimera Ant arc, through Morel and Knov, we learned a bit about the political undercurrent beneath the Chimera Ant arc. Pariston, who controlled the board, was stifling the Extermination Team and preventing Hunters from getting approved to join the team.
We know that Beyond has been preparing for over 50 years for this trip, and Pariston is working on Beyond's team.
So, I think Beyond brought back Chimera Ants from the Dark Continent, and along with his team, he bred the ants with a female human to create the Queen we know in the Chimera Ant arc.
They then calculatedly placed the Queen in the perfect environment for the Chimera Ants to grow a colony without being stomped out quickly.
I believe Beyond did all of this to get his father killed so he could go to the Dark Continent.