Definitely! My intro would be:
Sometimes people have the illusion to understand the world or feel confident about themselves, but the news is that there's an unknown probability that what we know about reality, encompassing scientific knowledge too, is just a tip of the iceberg, and even the concepts of matter and energy might not be fundamental to reality. Dimensions we cannot even conceive might exist or other abstraction. Let alone the fact we don't know if there's intelligent extraterrestrial life on other planets, that's just the surface of what we don't know.
Everything has an unknown probability to end at any moment for unknown reasons transcending what's intuitive yet most people do not realize that. Because we have no idea of how rich reality truly is and how interconnected we are to this richness.
Our brains might be too limited in their cognitive potentials/capabilities to understand what's truly fundamental or see the overall picture, and we relentlessly search for answers based on our logical and empirical human findings, yet as it stands there's an unknown probability that there's so much more out there we will never be able to even think about and maybe it's so abstract we literally cannot.
We are just squishy forms of life with a brain weighing about 3 pounds, inflating and deflating lungs, a beating heart constantly in motion that beats without our conscious control and we cannot stop unlike our breathing, complex cellular processes, and our bodies can be so fragile, including our psyche that can be so fragile, from the big questions to ordinary events that leave us in shock and traumatize us...