Ever wonder why Big Mom is the monstrous size that she is? Or why she has episodes of uncontrollable hunger pains? I believe that I have fond a possible answer to both questions.
In chapter 866 Big Mom was abandoned by her parents after causing so much damage, that exile was a merciful punishment. They tell her that if she waits for them, she can eat all the candy in her back pack that she wants. We learn that big Mom is obsessed with gigantification. Big Mom commissioned Ceaser to create a method of gigantification where you can make artificial giants as will. It was also noted that the world Government has quite a bit of interest in this as well. In chapter 684, we learned that Vegapunk was also trying to figure out gigantification for some time. He was trying in the events of Punk Hazzard. He also attempted it back when Ceaser blew up the lab and crossed too many lines where Vegapunk kicked him out of the group. since we do not know Vegapunk's age, we have no idea how long he has been experimenting with gigantification or if scientists before him also experimented with gigantification. In chapter 665, we learn about the drugged candies that Ceaser was feeding to the children he was experimenting on. We learned that the candy was laced with a substance known as NHC10. A stimulant when given in properly controlled doses, can he used to treat illnesses. However, when It is given too often, it becomes addictive. It can cause side affects such as pain, hallucinations, internal body damage, and etc. as far as I know, we do not know exactly how Ceaser was experimenting on the children. it could very well be in association with the NHC10, or using it as a catalyst of some kind. Meaning that the NHC10 is a crucial component to the gigantification process so far. It is even more likely due to NHC10 being a valuable drug that is not easy to get. Yes, Ceaser has connections to the black market. But why go through that much trouble for that specific drug if he could use any old drug that has similar properties? He could of even made up his own drug instead. Due to Ceaser being former colleagues with Vegapunk and is even using his old lab, we can assume Ceaser has access to some of Vegapunk's research and probably remembers what he had learned from Vegapunk. Meaning that Ceaser's Gigantification experiments are either built on or inspired by Vegapunk's versions of the same experiments. We know that Vegapunk supposedly works for the World Government and that he has worked with Gigantification in the past. It is woth noting that in Wano country, Chopper revealed that Ceaser helped him to improve the recipe for the rumble ball which is very candy like. Back in chapter 866, you can see that Big Mom's parents seem to be a normal size while Big Mom is rather...well...big. Even in the world of One Piece, it is a stretch to say that her mother gave birth to a child of that size. Meaning that if she is the mother, Big Mom at one point in time was a regular size as well. We do not know where Big Mom was born. It is very possible that she was born somewhere with higher levels of World Government influence. What if Big Mom was a early on victim to Vegapunk's version of the gigantification experiments where he also used candy as a catalyst? It is worth noting that Vegapunk got mad at Ceaser before he blew up the lab for proposing the idea of experimenting on children. However, we do not know if Vegapunk has always been that way or if something happened in the past that made him change his ways. something like one of his experiments going out of control on a rampage and causing a lot of destruction to where that child got exiled? If Big Mom ate gigantification candy as a child, it would explain her massive size and why her parents are normal size humans. After getting exiled, Big Mom no longer had access to the drugged candy after she ate all that was left for her in her bag. This would make her go into withdrawal and cause her to go on a rampage where she can only be calmed by what she is craving. What we know as her Hunger pains. Due to not having the access to the drugged candy, Big Mom would try to settle for other sweet alternatives to satisfy her urges. The side effects could explain the hunger pains and the addiction to sweets. After enough time has passed to where Big Mom has her famous intelligence network, It is possible that Big Mom eventually found out that the candy she ate was in fact drugged. However, finding that it was developed by Vegapunk and the World Government, she figures that it would be too risky and too much trouble to get it directly from the source. Assuming it would even still be available in the first place. With all of those experiments resulting as failures, they probably moved onto other means for gigantification. Since Big Mom can not get her gigantification candy from those who drugged her when she was a child, did the next best thing. Big Mom went to someone that used to work with Vegapunk who should be somewhat knowledgeable on the subject and commissioned them into making and perfecting the gigantification candy. Big Mom commissioned Ceaser to make and perfect her gigantification candy.
In chapter 866 Big Mom was abandoned by her parents after causing so much damage, that exile was a merciful punishment. They tell her that if she waits for them, she can eat all the candy in her back pack that she wants. We learn that big Mom is obsessed with gigantification. Big Mom commissioned Ceaser to create a method of gigantification where you can make artificial giants as will. It was also noted that the world Government has quite a bit of interest in this as well. In chapter 684, we learned that Vegapunk was also trying to figure out gigantification for some time. He was trying in the events of Punk Hazzard. He also attempted it back when Ceaser blew up the lab and crossed too many lines where Vegapunk kicked him out of the group. since we do not know Vegapunk's age, we have no idea how long he has been experimenting with gigantification or if scientists before him also experimented with gigantification. In chapter 665, we learn about the drugged candies that Ceaser was feeding to the children he was experimenting on. We learned that the candy was laced with a substance known as NHC10. A stimulant when given in properly controlled doses, can he used to treat illnesses. However, when It is given too often, it becomes addictive. It can cause side affects such as pain, hallucinations, internal body damage, and etc. as far as I know, we do not know exactly how Ceaser was experimenting on the children. it could very well be in association with the NHC10, or using it as a catalyst of some kind. Meaning that the NHC10 is a crucial component to the gigantification process so far. It is even more likely due to NHC10 being a valuable drug that is not easy to get. Yes, Ceaser has connections to the black market. But why go through that much trouble for that specific drug if he could use any old drug that has similar properties? He could of even made up his own drug instead. Due to Ceaser being former colleagues with Vegapunk and is even using his old lab, we can assume Ceaser has access to some of Vegapunk's research and probably remembers what he had learned from Vegapunk. Meaning that Ceaser's Gigantification experiments are either built on or inspired by Vegapunk's versions of the same experiments. We know that Vegapunk supposedly works for the World Government and that he has worked with Gigantification in the past. It is woth noting that in Wano country, Chopper revealed that Ceaser helped him to improve the recipe for the rumble ball which is very candy like. Back in chapter 866, you can see that Big Mom's parents seem to be a normal size while Big Mom is rather...well...big. Even in the world of One Piece, it is a stretch to say that her mother gave birth to a child of that size. Meaning that if she is the mother, Big Mom at one point in time was a regular size as well. We do not know where Big Mom was born. It is very possible that she was born somewhere with higher levels of World Government influence. What if Big Mom was a early on victim to Vegapunk's version of the gigantification experiments where he also used candy as a catalyst? It is worth noting that Vegapunk got mad at Ceaser before he blew up the lab for proposing the idea of experimenting on children. However, we do not know if Vegapunk has always been that way or if something happened in the past that made him change his ways. something like one of his experiments going out of control on a rampage and causing a lot of destruction to where that child got exiled? If Big Mom ate gigantification candy as a child, it would explain her massive size and why her parents are normal size humans. After getting exiled, Big Mom no longer had access to the drugged candy after she ate all that was left for her in her bag. This would make her go into withdrawal and cause her to go on a rampage where she can only be calmed by what she is craving. What we know as her Hunger pains. Due to not having the access to the drugged candy, Big Mom would try to settle for other sweet alternatives to satisfy her urges. The side effects could explain the hunger pains and the addiction to sweets. After enough time has passed to where Big Mom has her famous intelligence network, It is possible that Big Mom eventually found out that the candy she ate was in fact drugged. However, finding that it was developed by Vegapunk and the World Government, she figures that it would be too risky and too much trouble to get it directly from the source. Assuming it would even still be available in the first place. With all of those experiments resulting as failures, they probably moved onto other means for gigantification. Since Big Mom can not get her gigantification candy from those who drugged her when she was a child, did the next best thing. Big Mom went to someone that used to work with Vegapunk who should be somewhat knowledgeable on the subject and commissioned them into making and perfecting the gigantification candy. Big Mom commissioned Ceaser to make and perfect her gigantification candy.