Oda already emphasized how much of a role fodder play in wearing down a strong character. And Luffy, Zoro and Izo already specifically that the fodder in BP crew are strong, the fact that the SN ran away instead of just beating them all should tell you enough. They are not like ants, they are like puppies. Get enough puppies attacking you and even you will get scared and sort of tired after fending them off.
The only people so far who can solo a Yonko crew are BM and Kaido, BM because of her DF ability which is perfect for taking out multiple strong fodder who fear her nonetheless, Kaido because he is the raid boss master. Any other top tier will eventually be worn down fighting all the tens of thousands of fodder in a Yonko crew.