Is this beginning of Shippuden Kakashi? If so, the wildcard in the trio is Chiyo. As soon as Oro and Sasuke take down Chiyo, they get rid of Asuma and Kakashi very quickly.
If it is war arc Kakashi, then things get a bit more interesting. War arc Kakashi can take down Hebi Sasuke and Orochimaru may not be able to handle the trio at the same time.
The most important point here is: Asuma is the weak link in the trio and is nowhere at the level to compete with Akatsuki/Low Kage tier opponents, which actually includes Sasuke and Orochimaru. Moreover, depending on the timeline, one could rate Chiyo as the most dangerous person in the team since she, with Sakura acting as her puppet, was able to kill Sasori, which is a huge strength feat considering her age. Additionally, she fought against Tsunade a lot of times before, meaning that she quite possibly fought against Orochimaru too and is aware of his abilities. Last, but not least, she has stated that she has gone against Sharingan users, and implied that she even went against Mangekyo Sharingan users, a few times in the past and can handle Sasuke in that department. She is someone who would push Sasuke and Orochimaru to use their mid/high tier abilities despite her advanced age.