idk man but id doubt so. I think the most logical explanation is since Luffy is not the one being handcuffed, hes not severely weakened by just coming in contact with it. Yamato and Big Mom on the other hand were completely chained by the cuffs. His stamina and resistance also grew greater thanks to his training of lifting blocks in Udon prison while being handcuffed by seastones. He also coated his hands with advCoA that may also played a case on why that didnt affect him and why he was able to break her chains.
In manga, in udon prison while fighting dobberman (or some warden smile) he said he can't use haki because of seastone cuffs while he was hit by him.....
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