Imo I think if it does hint the fight is ending I see more of a 3rd party interruption happening rather than one or the other being defeated.
For Luffy, he's at the point where he doesn't really need to be vigor checked anymore after losing to Kaido for the first time. It'd be counter intuitive to his growth unless it's an arc where he gets a power up again.
For Kizaru, I'm lookin at it more at a storytelling perspective. He's a character that has been built up for a good while now, especially with minor hype moments like "Shall I go, Sakazuki." He's been doin good cashin in on that hype currently but it'd be dissapointing if he simply lost after a chapter without us seeing what he can truly do.
I'm thinkin either that robot below is gonna start rampaging, Kuma is gonna appear, or another kind of suprise appearance.