Current Sukuna can't use DE or Ten Shadows anymore, and can't use fast RCT now either. He should also have less than half of his CE left (though Gege has never really made CE reserves actually matter). Higuruma will likely accomplish something to further nerf him. We have yet to see how strong current Yuji is, but given that he was already high grade 1 level before the 1 month timeskip, that Yuji likely ate the 6 remaining Death Paintings to get a pretty substantial boost, and that he had 1 month to train, Yuji may be Special Grade Sorceror level now. Megumi will likely end up helping at some point. Yuta and Maki may show up to help depending on what happens with Kenjaku. Hakari can also help if he beats Uraume.
It's definitely an uphill battle, but I can see Sukuna losing given what we currently know. It largely depends on how big of a PU Yuji got.
I feel like there's too many villains these days with crybaby backstories. It feels nice to have an unabashedly evil villain sometimes