Shanks knew about it hence why he made a whole crew without no DF users( as far as we know)
Blackbeard went for the yami yami no mi especifically because it can cancel other people´s DF, maybe on it´s awakening he can ''nullify'' their existance absolving his crewmates from felling the effects of the illness while also doing this on himself.
Oda never solves a plot point without adding other 2, there is NO WAY that buggy and toki( only DF users in roger´s crew) got sick next to LT while everyone else was fine.
This connects perfectly with chopper´s dream, he will create the definitive cure for all illnesses, which will include the laugh tale one thus fulfilling his dream and also placing himself as the best doctor inside OP universe.
Blackbeard went for the yami yami no mi especifically because it can cancel other people´s DF, maybe on it´s awakening he can ''nullify'' their existance absolving his crewmates from felling the effects of the illness while also doing this on himself.
Oda never solves a plot point without adding other 2, there is NO WAY that buggy and toki( only DF users in roger´s crew) got sick next to LT while everyone else was fine.
This connects perfectly with chopper´s dream, he will create the definitive cure for all illnesses, which will include the laugh tale one thus fulfilling his dream and also placing himself as the best doctor inside OP universe.