It is a real possibility especially after Wano since Luffy's glazing was upped by Oda. In the story Sanji/Franky just got shot by lasers and Kizaru managed to get past them to almost kill Bonney/Kuma just before Luffy punched them him away, and Luffy turned the island to rubber to soften their fall, Zoro is still fighting Lucci and Jinbei is on his way to break them up, Robin is injured and getting transported by Nami/Ussopp/Chopper. Brooke is on the clouds moving the ship. That's the Straw Hats and off course it still a possibility that Sanji might get his roof top moment here, with him Luffy and Franky against Saturn and Kizaru. But at the same time it can't be discounted that Oda didn't give them the "they'll fight Kizaru/Saturn" portrayal (so far anyway). Especially after first they got frozen by Saturn as well.
Next, there is the non-straw hats. Bonney almost got killed by both Saturn and then Kizaru. Kuma turned into a vegetable after delivering his big moment punch, only for Saturn to regen and be no different to before. The "somebody arrived" was not Dragon or somebody to save them but just Dorry and Broggy who're probably there just to stall and bring them to Elbaf and also glaze Luffy, so imo that outs Bonney as a possibility as well. She seems to be the "princess in distress" of the arc, the one that needs saving, not save herself (like Yamato, and I'd say she even got her Yamato V Kaido moment against Saturn). Off course anything is possible. Kizaru Killing Saturn is even possible. But so is the most hype (for Luffy fans) possibility: Luffy 1 V 2 Saturn. I wouldn't normally stretch that far as a Luffy fan, but even I can see the extraordinary amounts of glaze Luffy is getting ever since Wano, would never have even expected it in WCI or something but I ain't discounting the possibility. Luffy beating Saturn this arc is what I'm personally putting all my stocks in this arc.
But I can see Luffy V Saturn/Kizaru 1 V 2 rn. Not holding out on it or expecting it, but ain't discounting the possibility:
Right now, Kizaru got punched down by Luffy. He shot up Sanji and Franky and would've killed Bonney/Kuma and both got frozen by Saturn before too.
Speaking of Saturn, he just mortally wounded Vegapunk in front of Luffy. This kinda feels like Oda is not setting Sanji/Franky to be the ones to fight Saturn....Or Kizaru (unless he got nerfed somehow). But it seems Kizaru is at least momentarily on the floor which would theoretically leave Luffy and Saturn standing off against each other. So I can see Luffy next throwing hands with Saturn next chapter, unless it pans off to somewhere else. Then there is Kizaru, yes, he might get back up, yes his there to body guard Saturn. So what will he do? I could see him attack Luffy, starting the 2v1.
Next, there is Kizaru's "uncertain justice". It feels like to me, he'll see what truly is "justice" watching Luffy and Saturn fight, or realising it somehow, which imo supports him 2v1ing at least initially. The strongest suggestion to me, at least is this:
Why does Oda need to feed Luffy to full power if all his there to do is briefly stall one of them and escape? This imo is the strongest evidence for Luffy at least having a full on fight with Saturn and defeating him. Kizaru of course is arguable that he won't get completely beaten senseless because he seems to be wavering and not 100% dead set evil. I feel like in almost every arc Luffy is on his last legs at the end of the arc or out after fighting and beating whatever villain was in the arc. So I can see a big all out "main" fight (with whomever) happening now, after his back up, if Oda's plan was for them to just escape and get away without anybody defeated, then he wouldn't have needed to feed Luffy here.
There are also the Blackbeard Pirates and vice admirals sneaking around. What purpose would they have to be introduced into this arc? I could honestly see Zoro/Jinbei encountering/detecting/getting tricked by the BB pirates in some way, remember that both are pretty much the masters of espionage, with Katerinas fruit and Laffites hypnosis. There are also 9 vice admirals, of which 8 are unaccounted for.
Overall, its a very real possibility that Luffy at least briefly 1v2s Kizaru and Saturn. So how would you react? Complain bad writing or respect Luffy?