Mihawk is similar to Dragon in that he maintains absolute detachment from others (at least publicly). With recent revelations that people who have personal relationships are preyed upon, and those who have no personal relationships are suspected of them being violated before, being likely, it stands to reason that Mihawk may have had a romantic partner and that she was violated by the World Government.
Basically, his loneliness, like Dragon's, is likely to be the result of knowing having loved ones is an exploitable weakness because they actually experienced it in the past.
Basically, his loneliness, like Dragon's, is likely to be the result of knowing having loved ones is an exploitable weakness because they actually experienced it in the past.