S-Hawk uses advanced swordsmanship techniques and Jinbe uses fishman karate. Skill is somehow engraved in those genes.
So yes, EoS's Luffy DNA would make a stronger Seraphim:
- Baby Luffy's would inherit Luffy's potential but would never reach it unless it underwent a similar life with a similar determination.
- EoS's Luffy would actual strength and skills instead of potential without having to work for it.
Interestingly, either Seraphims don't inherit haki or aren't immediately as strong as their original genetic donors (S-Hawk < Mihawk) but they're clearly hardcoded to have those skills as they develop without having to work for them like the originals.