Has Usopp tried to attack BM before? I don't think I could recall anything like that ever happening.
But, to answer your question, no, I don't think Zoro will have a hand in defeating BM or even attacking her. He has set his sight on Kaido, and that means he will have to either go through King or Queen.
Because, if he ever sees them, that means their defeat is nigh. We can't have the war end yet.