If any of the mid-tier Straw Hats are on the ropes, someone else will just come and assist them. Brook still doesn't have a fight yet and I doubt Nami and Usopp will lose their rematch against Page One and Ulti. Franky is doing really well against Franky. Brook will either (in my opinion) help Robin against Black Maria or help Carrot and Wanda against Perospero. Either way, I don't see anyone full-on losing (aside from Nami and Usopp the first time).