At first I thought the luffy panel was him getting enraged but maybe it's just him starting to take think on a serious level.
He's been goofing around with kidd since the beginning of the raid. Thinking of tama's situation might have been a wake up call of what is at stake.
So regarding his situation I think next chapter he's going to either look for kidd of kaido himself.
And of course if he loses his shit, we might see the start of the chaos in onigashima with queen going after luffy. I'm afraid he'll be nothing more than a hypetool for luffy if that's the case.
We may see big mom and her children arriving in the middle of the mess. And the F6 departing to look for yamato.