This is valid for 95+% of all df users.
Exceptions are Whitebeard, Akainu, Kuzan, Venus, Luffy, King, Kaido, Yamato, Shiryu, ID prisoners (supposedly, since they've been lowdiff oneshot several times by now).
Take Law's fruit away and usop might has a draw against him. Take 3B kid's fruit away and EL Luffy oneshots him like Bellamy.
Hancock casually oneshot multiple Pacifista without using her fruit. She did well by making BB sweat and oneshotting several YCs considering she was weakened by his fruit and also outnumbered. Not to forget she's a beautiful woman and we know how Oda generally treats beautiful women.