As we know, all of Zoro’s opponents are minorities.
However Mihawk doesn’t seem to be. At least not at first. Yet it is still possible that Mihawk belongs to a marginalized group.
Given the overt Christian symbolism surrounding this character, with his cross shaped blade, I find it hard to believe he is a religious minority. He also probably identifies as straight and cis due to this religious affinity.
That leaves one group left: disability.
Given that Mihawk clearly has no physical disabilities, his disability is likely to be intellectual
My guess is that he has autism. Mihawk seems to struggle socially, as many people with autism do. Whereas most other pirates with his bounty have some crew, Mihawk never had any crew before he joined cross guild.
Hell, Mihawk doesn’t seem to have any friends in general. He’s in his 40s and he doesn’t seem to have a family either. Rather he devoted his entire life to his obsession with swords.
This is very similar to Chris Chan, a famous autistic person irl, and his similarly solitary life devoted to his obsession with toys and cartoons.
Overall, I’m a very big Mihawk fan and I would love it if Oda explored Mihawk’s disability a bit more. Perhaps have him eventually overcome his poor social skills and become friends with Buggy and Crocodile.