Sakazuki ordered CP0 to wait for Marines:
Rob Lucci however manage to take-down Sentomaru and take-over the seraphim:
Luffy is alone, CP0 outnumber and outgun him and that's without consdiring how injured Sentomaru is liability...
The way I see it CP0 have clear advantage over the mere Yonkou if this situation escalate.
Sakazuki's order basically saved Luffy from CP0.

Rob Lucci however manage to take-down Sentomaru and take-over the seraphim:

Luffy is alone, CP0 outnumber and outgun him and that's without consdiring how injured Sentomaru is liability...
The way I see it CP0 have clear advantage over the mere Yonkou if this situation escalate.
Sakazuki's order basically saved Luffy from CP0.
