No, for 2 reasons.
#1 - Oda is physically incapable of giving a non-luffy fightlots of panel time. This fight needs 3 chapters worth of full focus.
#2 - Mihawk has no hype, no feats, and he's Zoro's master. It's the lamest setup for a conflict; and I don't give a damn what they do with that plotline. I'd rather someone else kill Mihawk beforehand.