So in that case
Luffy
-Nika fruit
Sanji
-Germa genes
Zoro
-Enma
If you have no proof that D clan gives Luffy special powers or something, then it is irrelevant.
Well no, because as I said, the Shimotsuki clan are famed for their toughness, as in durability/endurance, D clan have never been famed for having special strength, but either way, if you remove their families, they're still all about the same.