I don’t think Pizarro is going to get destroyed prior to the fight. I think he’ll be Coby’s fight, because imo it fits best.
Pizarros the one in charge of the slave camps and Coby is the kinda guy to focus on saving those wrongly captured there. Plus by taking down Pizarro, he gets a direct comparison with old Garp who’s strongest attack nearly cracked the skull, Coby feels like he’ll end up doing more to finish that fight. Plus it’s a common trope, “Hero vs Corrupt King”
I think that’s more odas route, while the straw hats fight the Blackbeard pirates, Coby will be attacking Pirate Island and destroying it.