Todoroki, pulling off absolute zero ice that ignore durability.
Just imagine how some people would lose their s**t if the students actually won against the guy.
Todoroki could freeze him.
Creati could pull off some strategies.
The mushroom girl could infect his lungs with poisonous shrooms.
The reptile girl and Shoji could act as decoys.
Kaminari could zap him good.
Mineta could throw his balls at him and stick him onto his own body.
Ashido could melt his face off with her acid.
And then Shinsou comes in and bam brainwashed.
Then Shigaraki is about to recover from Endeavor's attack, sees Machia and is like "Let's destroy everything now!" and Machia just knocks him out good. Then he sees Shigaraki out cold and escapes with him since he wants to protect him.
Then everyone counts their losses during the aftermath of this war.