It is possible. But,
I think Kaku will be look like he still can keep up with Zoro. Well, if Zoro used Sword, Kaku is the one who will intercept Zoro with Sword, not Lucci.
I think Lucci & Seraphim will go to Vegapunk, while Kaku & Co (maybe stussy, maybe others) stall Zoro. Cp0 look like convincingly on the upper hand, while Zoro just play a base. Zoro can't do more if he is on the Ship. In the end either in the ship or on the shore, Zoro interrogates injured Kaku & Co that gets tied up. Brook is having a cup of coffee actually.
......
Kaku: You underestimate Lucci.
Zoro: You guys the one who underestimate my captain..... I, myself want more actually, this isnt enough for my boredom. Like... I want to cut that nosebleed scum guy
Sanji:. Ah choo
........
I have no hope of a good fight on the side characters.