ISDS is Zoro's ougi and most powerful move, takes long to set up so is impractical in duels.
Shishisonson is a quick finisher with the most penetrating power, great for humanoid opponents with mediocre reflexes.
Asura is a happy medium, not as powerful as ISDS and not as fast as Shishisonson.
Zoro's moves all serve their different purpose, it's not that difficult.