No, but his three biggest impacts were;

Chuunin Exams โ€” Caused the deaths of children
ANBU โ€” Good and bad, it's been abused maliciously by those who followed Tobirama.
Police Force โ€” Created discrimination and disdain for the Uchiha.

So in his short time period he establishes a shady group that causes problems down the road, creates a root cause for Uchiha discrimination and has the Chuunin exams lol. Then dies.
Chuunin exams- The kids have to learn to be strong through adversity. It's much better than them learning through war.

Anbu- it ain't Tobirama's fault that dicks like danzo fucked it up. And that whole fuck up along with the uchiha massacre was on the watch of Third hokage. He didn't do anything to prevent it or spiraling out of control.

Uchiha- The uchiha, as explained in the series, were a dangerous group. And he gave them purpose. The main problems that lead to the uchiha massacre were Hiruzens inactions and letting danzo do as he pleases, and the distrust of the uchiha during the nine tails incedent, which was orchestrated by obito, and uchiha.

Its not like tobirama did those things with the intention of harm. Just like the justsu's he developed like the reanimation jutsu, they were used by bad people for bad things. Doesn't mean they haven't had good effect on the leaf.
Who knows where the leaf would be without Tobirama laying the ground work for a more structured and organized village.
 
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