yes, if base Luffy is doing this to Kaido, Zoro can do better due to having higher lethality /AP and having the same power advcoc.
this is what base luffy said about base Zoro (so it is what you see fighiting Kaido):
Luffy wow in an istant, never saw that comment for Kaido - Zoro slashes are that fast, effective that Luffy think they are istant!
this is how Oda potrayed Luffy&Zoro speed in the same panel (basically Oda is confirming that they are equal) which is what Luffy is using to fight Kaido:
About defense, we saw how good Zoro defense are when takking Hakkai (if Zoro didnt have block he would be dead) as also vs King.
Zoro reaction is one of the best in Onigashima (check King).
Zoro lethality and Ap > Luffy.
Yes Zoro can fight Kaido and to better than what we are seeing right now with Luffy.