A woman is a woman, a man is a man... there isn't anything out there that's going to change that. All that other stuff is bullshit, irrelevant. Just because I want to be something doesn't mean I can or will. Unless we humans can actually adapt/evolve to doing something like that... No.
As for Yamato, I think its fine, she's inspired by Oden and wanted to become him in a way. A woman can be manly...
But for myself, once it steps into butch territory, No. That's my opinion.