In all seriousness, Luffy will have his serious moments again with key enemies.
Its clear VP is surviving, and the way oda writes scenes is generally separate from how characters experience situations which is super unrealistic.
I would "assume" Akainu will piss him off, and maybe theres a thing with Nika/Gear 5 where anger is a power trait over laughter. I also "assume" that with Blackbeard, he could just take that power away, so no more Nika.
And even with Shanks, we'd have to see how much hed now how to handle that fruit since he gave it to Luffy.
Imu out of all of this I feel Imu will be the most ridiculous, and itll be entirely on purpose to send this series off with the most ridiculous fight Oda can think of.