Following a successful clinical trial investigating uterine transplantation (UTx) in Sweden, resulting in eight live births so far,3 UTx appears to be a viable therapeutic option for women with absolute uterine factor infertility (AUFI). More than 42 UTx procedures have now been performed globally, and at least 12 live births have been reported. Following the establishment of the International Society of Uterine Transplantation (ISUTx), and the formation of research teams globally, it is anticipated that UTx will make the transition from research to clinical care in the future. Following these developments, speculation has escalated regarding the possibility of performing UTx in male to female (M2F) transgender women, which would enable them to gestate and give birth to their own children.4