Honestly...I hate it when some specific group call Oda a homophobic ! He is pretty vocal when it comes to identify his drawn characters as Okama. For example Morley , Bon Clay , Ivankov and Kiku.
Sometimes by their appearance , their intraction etc.
Even with Kiku , you can see her dialogue where she say , "I'm women by heart"
In case of Yamato , Oda went out of the route and let her remind us every panel of her , that she is obsessed with being Oden (who is happened to be a man)
On top of that , he even gave us her intro box where specifically mentioned her as Kaido's daughter. Which one should have accepted as official confirmation. Because Oda is the one who introduced me to "Okama" term (as non japanese) for trans characters . I've never seen this word in other manga I've read