After 100 hours of game, this is my tier-list:
S+: Kaido, Whitebeard
S: Mihawk, Big Mom, Katakuri, Akainu, Shanks,Kizaru
A: Luffy, Zoro, Reiju, Cavendish, Fujitora, Kuzan, Marco, Smoker,Lucci, Sanji, Ace, Carrot
B: Doflamingo, Jinbe, Sir Crocodile, Hancock, Ichiji, Tashigi, Sabo, Kidd, Hawkins, Niji, Law, Yonji, Invankoff
C: Franky, Nami , Brook, Capone, Buggy
D: Robin, Chopper, Bartolomeo, Usopp