he wheezing is normal. He doesn't control Enma properly yet, and he must have sent a huge chunk of Haki on that attack. Haki is an expendable resource, so it must take a toll on you using huge amounts on a single attack. He was in mid air, doesnt have geppou or law TP. He can't dodge a lightning that have a mind on its own and can follow people. Nothing out of the ordinary.
Tbf she's also shivering from Luffy on the last page. I get that this is a big deal but lol these yonko haven't even gotten serious yet. Big mom barely using her strength and sword, let alone soul powers outside of her 3 homies. Kaido hasn't even gone hybrid. Neither have shown awakening. This is gonna be a massively brutal fight