I mean the amount of foreshadowing for the fall of the old generation here in Wano is just insane.
Then we have a narrator card saying that The Tower card means 'Destruction of the old' and 'New way' while it focuses on Kid smiling. I just don't have a doubt that both Big Mom and Kaido are falling here in Wano.
Big Mom won't fight Luffy, it would be the most anticlimactic and boring fight of the whole series, specially after he beats Kaido (regardless if he needed help or not).
Big Mom serves no narrative purpose after Wano, she simply has to be removed from the equation either by becoming a neutral figure or by being defeated. Her being defeated is the most likely option as it has also being heavily foreshadowed that Katakuri will take charge of the Big Mom Pirates.
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I mean on Kaido's favour he speed blitzed Luffy who was using future sight and from the Rooftop 5, Luffy is for sure the fastest one there.
Kaido is just willing to take blows and counter attack but in no way that guy is slow.